Browsing by Type "journal article"

This paper describes the necessity of the Electronic Resource Management System CORAL for libraries in the contemporary digital world. It explains the importance of the open-source Electronic Resources Management System CORAL, the prerequisites for its installation and its featured modules. The paper reveals that CORAL is an excellent software that can help library professionals in managing various categories of electronic resources. And unveiled that the installation and maintenance of CORAL is quite easy.

This is a study of a rare seventeenth century palm-leaf manuscript named the Grahaṇamukura, which has been carefully preserved in a private collection for more than 400 years. This manuscript was used to calculate eclipses, and has bilingual text, with verses in Sanskrit and a commentary in Kannaḍa, a southern Indian language. It is a handy manual for the prediction of eclipses following the methods prescribed in treatises. In the absence of the name of the author anywhere in the text, we conjecture that it was written by the father–son duo, Demaṇa Joyisaru and Śaṅkaranārāyaṇa Joyisaru of Sringeri. In this paper the contents of the text are summarized.

The quantum dots (QD) interface in solution can significantly influence electron transfer dynamics, impacting quantum-dot-sensitized solar cells as well as various biological, environmental, and industrial systems. Here, we propose a method to identify the contribution of quantum dots’ interface-created static electric field to the nonlinear optical response (NLO) due to four-wave mixing (FWM), especially for the nanoparticles where surface contribution is high. We implement a way to disentangle the FWM response in QDs, originating from the three incoming oscillating laser fields (NLOoscillating) and a contribution (NLOstatic) arising from the three oscillating laser fields and the static electric field caused by the interface. Advanced two-dimensional electronic spectroscopy (2DES) employs phase-resolved heterodyne techniques where the FWM response is measured in a particular phase-matched direction and the response is distinctively phase sensitive. Theoretical analysis shows that alterations in the interface can introduce phase variation in the NLOstatic signal resulting in distinct changes in 2D spectra. Our studies establish a range of ionic strength (10–6 M < x < 10–3 M), which can be important to untwine, the usual NLO signal (NLOoscillating) from the NLO (NLOstatic) contributed by the interface of quantum dots. This analysis could open up possibilities for studying various dynamics occurring specifically at the interface and also paves the way for exploring different ion interactions through phase changes in 2D spectra. Additionally, it offers enormous scope for employing deep learning-assisted phase recognition.

The bluetongue virus (BTV), transmitted by biting midges, poses a significant threat to livestock globally. This orbivirus induces bluetongue disease, leading to substantial economic losses in the agricultural sector. The current control measures have limitations, necessitating the development of novel, efficient vaccines. In this study, an immunoinformatics approach is employed to design a multi-epitope subunit vaccine for Ovis aries targeting six BTV serotypes. Focusing on the VP2 capsid protein, the vaccine incorporates B-cell, helper-T lymphocytes (HTL), and cytotoxic T-cell lymphocytes (CTL) epitopes. Molecular docking reveals stable interactions with TLR2 and TLR4 receptors, suggesting the stability of the complex, indicating the potential viability of the multi-epitope vaccine. The computational approach offers a rapid and tailored strategy for vaccine development, highlighting potential efficacy and safety against BTV outbreaks. This work contributes to understanding BTV and presents a promising avenue for effective control.

Why cancer cells disproportionately accumulate polyubiquitinated proteotoxic proteins despite high proteasomal activity is an outstanding question. While mis-regulated ubiquitination is a contributing factor, here we show that a structurally-perturbed and sub-optimally functioning proteasome is at the core of altered proteostasis in tumors. By integrating the gene coexpression signatures of proteasomal subunits in breast cancer (BrCa) patient tissues with the atomistic details of 26S holocomplex, we find that the transcriptional deregulation induced-stoichiometric imbalances perpetuate with disease severity. As seen in luminal BrCa cell lines, this imbalance limits the number of double-capped 19S-20S-19S holocomplexes (30S) formed and promotes free 20S catalytic core accumulation that is widely-believed to confer survival advantage to tumors. By retaining connectivity with key tumor 19S:20S interface nodes, the PSMD9 19S subunit chaperone emerges as a crucial regulator of 26S/30S:20S ratios sustaining tumor cell proteasome function. Disrupting this connectivity by depleting PSMD9 in MCF7 cells introduces structural anomalies in the proteasome, and shifts dependence from 20SHigh to a deregulated 26SHigh state invoking anti-tumor responses which opens up clinically-relevant therapeutic possibilities.

The soil has a wide variety of microorganisms that are part of a varied ecosystem that includes plants. It has long been understood that some of these microorganisms, such as nitrogen-fixing symbiotic bacteria or mycorrhizal fungi, play significant roles in plant performance by enhancing mineral nutrition. However, only recently have researchers begun to identify the full range of microorganisms connected to plants and their potential to replace artificial agricultural inputs. The understanding of the make-up and behaviour of rhizospheric microbiomes has advanced significantly in recent years. Long-term use of these fertilisers frequently results in a drop in pH and exchangeable bases, rendering them inaccessible to crops and lowering agricultural productivity. Farmers have become increasingly reliant on chemical sources of nitrogen and phosphorus to solve this issue and increase plant yields.

We examine the performance of private and public mutual fund equity schemes in India. We use yearly NAVs of one eighty-nine equity schemes, Sensex and Treasury bill yield for the study period from April 2006 to March 2021. We apply time series plot, Quandt likelihood ratio (QLR) test, cumulative sum (CUSUM) test, compounded annual growth rate (CAGR using Geo-mean), performance measures and comparison with Sensex. The time series plot QLR test shows no structural break in the data and no change in parameter. Further results show no significant difference between private and public sector mutual fund equity schemes.

The purpose of this research was to explore how computer-assisted learning has impacted this generation and the impact it will have on our future generations to come. This paper shows the level of difference in the learning process of students and the achievement associated with it. Computer-assisted learning helps provide education with various multimedia platforms containing required information for easy and user-friendly learning of students. It stimulates innovative ideas to be induced into learning methodology. For over a decade we have been using various tools to enhance learning using computer based platforms such as smart classes, videos, and online courses with better resources. This has proven effective in the lives and academic success of the students when compared to traditional learning methodology. This method is most suitable for young kids than the older generation. Computer-based learning has become a fun way of learning and this method could be the future, almost replacing the conventional learning system. This form of learning had come to the rescue during the pandemic. With kids learning a lot from the internet, it has become a trend to learn this way and grasp things online without which learning cannot go any faster. In this digital world where new technologies are being introduced every few months, it’s high time to incorporate this innovation into enhanced learning for students and kids. The level of convenience and flexibility are the key points in this research. It also describes the success of the proposed methodology which can be a revolution in education.